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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers

Fig. 3

Development and internal validation of a diagnostic model (5hLD-score) based on tumor-shared 5hmC-modified lncRNA genes. A Unsupervised hierarchical clustering and heatmap of tissue-shared 5hmC-modified lncRNA gene markers in the training cohort. Statistical significance was determined using Chi-square test. Receiver operating characteristic curve (left panel) and boxplot (right panel) of the 5hLD-score for cancer detection in the B training and C internal validation cohorts. Statistical significance was determined using Wilcoxon rank-sum test. CC, colon cancer; GC, gastric cancer; HCC, hepatocellular carcinoma; AUC, area under the curve; 5hLD-score, 5hmC-LncRNA diagnostic score

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