Fig. 1
From: Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA
Schematic epigenetic modifications in cirDNA that regulate chromatin organization and gene expression. Epigenetic processes mainly consist of histone modifications including acetylation, phosphorylation, ubiquitination and histone methylation. Besides, DNA methylation consists of C5-methylation, C5-hydromethylation and N6-methylation. Black bold and purple thin strands display double strand DNA and histone tails, respectively