Association of peripheral blood DNA methylation level with Alzheimer’s disease progression

Table 1 List of DMPs with BACON-corrected P values less than Bonferroni correction threshold^a

Name	Chr	Pos	GencodeCompV12	Beta	Ave M-value	t	Before BACON correction		After BACON correction		Phenotype
Name	Chr	Pos	GencodeCompV12	Beta	Ave M-value	t	P value	Adjusted P value	P value	Adjusted P value	Phenotype
Without APOE4 covariate in the model
cg00386386	Chr9	136,216,149	MED22;RPL7A;SNORD24;SNORD36B;SNORD36A	− 0.97	1.97	− 6.14	4.12E⁻⁰⁹	3.56E⁻⁰³	6.50E⁻⁰⁹	5.61E⁻⁰³	mPACC_digit
cg09422696	Chr8	144,626,190	RP11-661A12.5	− 1.63	1.89	− 5.27	2.45E⁻⁰⁷	2.12E⁻⁰¹	1.17E⁻⁰⁸	1.01E⁻⁰²	CDR-SB
With APOE4 covariate in the model
cg00386386	Chr9	136,216,149	MED22;RPL7A;SNORD24;SNORD36B;SNORD36A	− 0.97	1.97	− 6.17	3.59E⁻⁰⁹	3.10E⁻⁰³	6.34E⁻⁰⁹	5.48E⁻⁰³	mPACC_digit
cg09422696	Chr8	144,626,190	RP11-661A12.5	− 1.65	1.89	− 5.38	1.41E⁻⁰⁷	1.22E⁻⁰¹	9.87E⁻⁰⁹	8.53E⁻⁰³	CDR-SB

CDR-SB Clinical Dementia Rating Scale Sum of Boxes, chr chromosome, GencodeCompV12 GENCODE Comprehensive database version 12 containing all transcripts at protein-coding loci, mPACC_digit modified Preclinical Alzheimer Cognitive Composite that used Digit Symbol Substitution Test, Pos position in reference to genome build hg19
^aP = 5.79 × 10⁻⁸