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Table 2 Results of EWASs of CHD risk factors in blood with incident CHD follow-up

From: DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Authors

Traits of interest in EWASs

Sample size

Ancestry

Array type

CpGs

Genes

Gene/RNA/protein full names

Aslibekyan et al. 2018 [37]

TNF-α

Discovery: 4794

Discovery: European

450k array

cg16411857

NLRC5

NLR family CARD domain containing 5

Replication: 816

Replication: European

cg07839457

iCHD: 1895 cases, ≤ 9566 controls

iCHD follow-up: multiple ancestries

cg00959259

DTX3L; PARP9

Deltex E3 ubiquitin ligase 3L

cg08122652

Poly(ADP-ribose) Polymerase family member 9

Hedman et al. 2017 [38]

TG, HDL-cholesterol

Discovery: 2306

European

450k array

cg27243685

ABCG1

ATP binding cassette subfamily G member 1

Replication: 2025

iCHD: 193 cases, ≤ 2113 controls

Campanella et al. 2018 [42]

Waist-to-height ratio

Discovery: 1941

European

450k array

cg12593793

LMNA

Lamin A/C

Replication: 358

iCHD: 131 cases, 195 controls

Fernández-Sanlés et al. 2018 [46]

Age-independent cardiovascular risk

Discovery: 645

European

450k array

cg12547807

LOC100506022

Long intergenic non-protein coding RNA 02606

Replication: 2542

iCVD: 222 cases, ≤ 1950 controls

cg27537125

MIR4425

MicroRNA 4425

cg05951221

AC068134.6; ALPPL2

/

cg21566642

Alkaline phosphatase, placental-like 2

cg05575921

AHRR

Aryl-hydrocarbon receptor repressor

cg19939077

PPIF

Peptidylprolyl isomerase F

cg00574958

CPT1A

Carnitine palmitoyltransferase 1A

cg18608055

SBNO2

Strawberry notch homolog 2