Skip to main content

Table 1 Results from epigenome-wide association studies of incident CHD in blood (iCHD cases > 100)

From: DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Study

CHD outcome or phenotype

Sample size

Ancestry

Array type

CpGs or GRCh37/hg19 locations

Genes

Gene name

Guarrera et al. 2015 [26]

Incident MI

Discovery: 292 cases, 292 controls

European

Discovery: 450k array

Region consisting of 15 CpG sites (chr6: 31867698–31867919)

ZBTB12

Zinc finger and BTB domain containing 12

Replication: 317 cases, 262 controls

Replication: MALDI-TOF mass spectrometry methylation assay

Westerman et al. 2019 [30]

Incident MI, angina, revascularisation, stroke and coronary death

Discovery: 1009 cases, ≤ 1014 controls

Discovery: multiple ancestries

450k array

Region consisting of 3 CpG sites (chr1: 27440462–27440721)

SLC9A1

Solute carrier family 9 member A1

Replication: 305 cases, ≤ 2282 controls

Replication: European

Region consisting of 6 CpG sites (chr19: 47287777–47288263)

SLC1A5

Solute carrier family 1 member 5

Region consisting of 6 CpG sites (chr17: 76037034–76037562)

TNRC6C

Trinucleotide repeat containing adaptor 6C

Agha et al. 2019 [34]

Incident unstable angina, MI, coronary revascularization, coronary death

1895 cases, ≤ 9566 controls

Multiple ancestries

450k array

cg22617878

ATP2B2

ATPase plasma membrane Ca2+ transporting 2

cg13827209

TGFBR1

Transforming growth factor beta receptor 1

cg14185717

BNC2

Basonuclin 2

cg10307345

PTPN5

Protein tyrosine phosphatase non-receptor type 5

cg13822123

PSME4

Proteasome activator subunit 4

cg23245316

TSSC1

Tumour suppressing subtransferable candidate 1

cg24977276

GTF2I

General transcription factor IIi

cg24447788

PTBP1

Polypyrimidine tract binding protein 1

cg08422803

ITGB2

Integrin subunit beta 2

cg01751802

KANK2

KN motif and ankyrin repeat domains 2

cg02449373

FUT1

Fucosyltransferase 1

cg02683350

ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif 2

cg05820312

TRAPPC9

Trafficking protein particle complex 9

cg06639874

MLPH

Melanophilin

cg06582394

CASR

Calcium sensing receptor

cg02155262

AGA

Aspartylglucosaminidase

cg12766383

UBR4

Ubiquitin protein ligase E3 component N-recognin 4

cg05892484

MAD1L1

Mitotic arrest deficient 1 like 1

cg03031868

ESD

Esterase D

cg25497530

PTPRN2

Protein tyrosine phosphatase receptor type N2

cg06596307

IGF1R

Insulin-like growth factor 1 receptor

cg10702366

FGGY

FGGY carbohydrate kinase domain containing

cg26470101

DLX2

Distal-less homeobox 2

cg26042024

ZFAT

Zinc finger and AT-hook domain containing

cg00466121

ZNHIT6

Zinc finger HIT-type containing 6

cg04987302

OTX2-AS1

OTX2 antisense RNA 1

cg08853494

RCHY1; THAP6

Ring finger And CHY zinc finger domain containing 1

THAP domain containing 6

cg26467725

SLCO3A1

Solute carrier organic anion transporter family member 3A1

cg06442192

ZNF541

Zinc finger protein 541

cg00393373

ZNF518B

Zinc finger protein 518B

cg22871797

CYFIP1

Cytoplasmic FMR1 interacting protein 1

cg18598861

IRF9

Interferon regulatory factor 9

cg09777776

ZNF254

Zinc finger protein 254

cg20545941

MPPED1

Metallophosphoesterase domain containing 1

cg19935845

TNXB

Tenascin XB

cg24423782

MIR182

MicroRNA 182

cg19227382

CDH23

Cadherin related 23

cg03467256

HPCAL1

Hippocalcin like 1

cg25196881

THBS1

Thrombospondin 1

cg02321112

MNX1-AS1

MNX1 antisense RNA 1

cg00355799

LOC339529

/

cg17556588

PRRG4

Proline-rich And Gla domain 4

cg07289306

MIR138-1

MicroRNA 138-1

cg22618720

MIR5095

MicroRNA 5095

cg14010194

GUCA1B

Guanylate cyclase activator 1B

cg24318598

ANO1

Anoctamin 1

cg07015775

ZNHIT6

Zinc finger HIT-type containing 6

cg21018156

LINC01312

Long intergenic non-protein coding RNA 1312

cg07475527

RCAN3

RCAN family member 3

cg20000562

SFTA3

Surfactant associated 3

cg07436807

STAMBPL1; ACTA2

STAM binding protein like 1

Actin alpha 2, smooth muscle

cg14029912

BHLHE40

Basic helix-loop-helix family member E40

Navas-Acien et al. 2021 [36]

Incident fatal and nonfatal CHD include MI and coronary deaths

Discovery: 748 cases, ≤ 1573 controls

Replication: 1145 cases, ≤ 5902 controls

Discovery: American Indian

Replication: multiple ancestries

Discovery: EPIC array

Replication: 450 k array

cg01620164

FIGN

Fidgetin, microtubule severing factor

cg12479512

RBSN

Rabenosyn, RAB effector

cg16604233

COL11A2

Collagen type XI alpha 2 chain

cg07964553

NEUROG2

Neurogenin 2

cg22293458

VPS8

VPS8 subunit of CORVET complex

cg26955383

CALHM1

Calcium homeostasis modulator 1

cg02628823

MGAT4D

MGAT4 family member D

cg01297357

ASIC1

Acid sensing ion channel subunit 1

cg09926486

FRMD5

FERM domain containing 5

cg08622677

PRMT8

Protein arginine methyltransferase 8