Study | CHD outcome or phenotype | Sample size | Ancestry | Array type | CpGs or GRCh37/hg19 locations | Genes | Gene name |
---|---|---|---|---|---|---|---|
Guarrera et al. 2015 [26] | Incident MI | Discovery: 292 cases, 292 controls | European | Discovery: 450k array | Region consisting of 15 CpG sites (chr6: 31867698–31867919) | ZBTB12 | Zinc finger and BTB domain containing 12 |
Replication: 317 cases, 262 controls | Replication: MALDI-TOF mass spectrometry methylation assay | ||||||
Westerman et al. 2019 [30] | Incident MI, angina, revascularisation, stroke and coronary death | Discovery: 1009 cases, ≤ 1014 controls | Discovery: multiple ancestries | 450k array | Region consisting of 3 CpG sites (chr1: 27440462–27440721) | SLC9A1 | Solute carrier family 9 member A1 |
Replication: 305 cases, ≤ 2282 controls | Replication: European | ||||||
Region consisting of 6 CpG sites (chr19: 47287777–47288263) | SLC1A5 | Solute carrier family 1 member 5 | |||||
Region consisting of 6 CpG sites (chr17: 76037034–76037562) | TNRC6C | Trinucleotide repeat containing adaptor 6C | |||||
Agha et al. 2019 [34] | Incident unstable angina, MI, coronary revascularization, coronary death | 1895 cases, ≤ 9566 controls | Multiple ancestries | 450k array | cg22617878 | ATP2B2 | ATPase plasma membrane Ca2+ transporting 2 |
cg13827209 | TGFBR1 | Transforming growth factor beta receptor 1 | |||||
cg14185717 | BNC2 | Basonuclin 2 | |||||
cg10307345 | PTPN5 | Protein tyrosine phosphatase non-receptor type 5 | |||||
cg13822123 | PSME4 | Proteasome activator subunit 4 | |||||
cg23245316 | TSSC1 | Tumour suppressing subtransferable candidate 1 | |||||
cg24977276 | GTF2I | General transcription factor IIi | |||||
cg24447788 | PTBP1 | Polypyrimidine tract binding protein 1 | |||||
cg08422803 | ITGB2 | Integrin subunit beta 2 | |||||
cg01751802 | KANK2 | KN motif and ankyrin repeat domains 2 | |||||
cg02449373 | FUT1 | Fucosyltransferase 1 | |||||
cg02683350 | ADAMTS2 | ADAM metallopeptidase with thrombospondin type 1 motif 2 | |||||
cg05820312 | TRAPPC9 | Trafficking protein particle complex 9 | |||||
cg06639874 | MLPH | Melanophilin | |||||
cg06582394 | CASR | Calcium sensing receptor | |||||
cg02155262 | AGA | Aspartylglucosaminidase | |||||
cg12766383 | UBR4 | Ubiquitin protein ligase E3 component N-recognin 4 | |||||
cg05892484 | MAD1L1 | Mitotic arrest deficient 1 like 1 | |||||
cg03031868 | ESD | Esterase D | |||||
cg25497530 | PTPRN2 | Protein tyrosine phosphatase receptor type N2 | |||||
cg06596307 | IGF1R | Insulin-like growth factor 1 receptor | |||||
cg10702366 | FGGY | FGGY carbohydrate kinase domain containing | |||||
cg26470101 | DLX2 | Distal-less homeobox 2 | |||||
cg26042024 | ZFAT | Zinc finger and AT-hook domain containing | |||||
cg00466121 | ZNHIT6 | Zinc finger HIT-type containing 6 | |||||
cg04987302 | OTX2-AS1 | OTX2 antisense RNA 1 | |||||
cg08853494 | RCHY1; THAP6 | Ring finger And CHY zinc finger domain containing 1 | |||||
THAP domain containing 6 | |||||||
cg26467725 | SLCO3A1 | Solute carrier organic anion transporter family member 3A1 | |||||
cg06442192 | ZNF541 | Zinc finger protein 541 | |||||
cg00393373 | ZNF518B | Zinc finger protein 518B | |||||
cg22871797 | CYFIP1 | Cytoplasmic FMR1 interacting protein 1 | |||||
cg18598861 | IRF9 | Interferon regulatory factor 9 | |||||
cg09777776 | ZNF254 | Zinc finger protein 254 | |||||
cg20545941 | MPPED1 | Metallophosphoesterase domain containing 1 | |||||
cg19935845 | TNXB | Tenascin XB | |||||
cg24423782 | MIR182 | MicroRNA 182 | |||||
cg19227382 | CDH23 | Cadherin related 23 | |||||
cg03467256 | HPCAL1 | Hippocalcin like 1 | |||||
cg25196881 | THBS1 | Thrombospondin 1 | |||||
cg02321112 | MNX1-AS1 | MNX1 antisense RNA 1 | |||||
cg00355799 | LOC339529 | / | |||||
cg17556588 | PRRG4 | Proline-rich And Gla domain 4 | |||||
cg07289306 | MIR138-1 | MicroRNA 138-1 | |||||
cg22618720 | MIR5095 | MicroRNA 5095 | |||||
cg14010194 | GUCA1B | Guanylate cyclase activator 1B | |||||
cg24318598 | ANO1 | Anoctamin 1 | |||||
cg07015775 | ZNHIT6 | Zinc finger HIT-type containing 6 | |||||
cg21018156 | LINC01312 | Long intergenic non-protein coding RNA 1312 | |||||
cg07475527 | RCAN3 | RCAN family member 3 | |||||
cg20000562 | SFTA3 | Surfactant associated 3 | |||||
cg07436807 | STAMBPL1; ACTA2 | STAM binding protein like 1 | |||||
Actin alpha 2, smooth muscle | |||||||
cg14029912 | BHLHE40 | Basic helix-loop-helix family member E40 | |||||
Navas-Acien et al. 2021 [36] | Incident fatal and nonfatal CHD include MI and coronary deaths | Discovery: 748 cases, ≤ 1573 controls Replication: 1145 cases, ≤ 5902 controls | Discovery: American Indian Replication: multiple ancestries | Discovery: EPIC array Replication: 450 k array | cg01620164 | FIGN | Fidgetin, microtubule severing factor |
cg12479512 | RBSN | Rabenosyn, RAB effector | |||||
cg16604233 | COL11A2 | Collagen type XI alpha 2 chain | |||||
cg07964553 | NEUROG2 | Neurogenin 2 | |||||
cg22293458 | VPS8 | VPS8 subunit of CORVET complex | |||||
cg26955383 | CALHM1 | Calcium homeostasis modulator 1 | |||||
cg02628823 | MGAT4D | MGAT4 family member D | |||||
cg01297357 | ASIC1 | Acid sensing ion channel subunit 1 | |||||
cg09926486 | FRMD5 | FERM domain containing 5 | |||||
cg08622677 | PRMT8 | Protein arginine methyltransferase 8 |