Fig. 3

Functional annotation of genes associated with significantly upregulated H3K27ac regions in 18-week-old stunted children. a Genome browser snapshot of H3K27ac signal tracks showing a representative region in which the normalized coverage increased with decreasing ΔHAZ (18 wk) score, i.e. H3K27ac was higher in stunted children. The color of individual signal tracks corresponds to the ΔHAZ (18 wk) scores. Genes associated with the highlighted region are labeled. b Biological terms (databases: GO biological process, KEGG, Rectome, WikiPathways) that were significantly enriched for genes associated with differential H3K27ac regions in 18-week-old children. Each node is a biological term, the node size corresponds to the term size, the node color indicates the significance of enrichment (bright orange: low q-value, light orange: higher q-value, all q-values < 0.05), and the edges are based on the number of genes shared between terms. Groups of terms were manually organized in different colored clusters with the summary term for the cluster shown in the label with the same color. c Gene network constructed with STRING (see “Methods” section) using genes found in the highlighted biological terms in b. Red genes belong to the “viral processes” GO term