Fig. 3

Methylation levels stratified by location of significant differentially methylated CpGs between JPA and EUA. Average methylation levels for each sample within CpG islands and surrounding regions are shown in promoters (top panel), non-promoters (middle panel), and intergenic regions (bottom panel). Blue corresponds to EUA, and red corresponds to JPA. Differences in average methylation for EUA and JPA in each region were tested using unpaired Welch’s t test (**** P < 0.0001, *** 0.0001 to 0.001, ** 0.001 to 0.01, * 0.01 to 0.05, NS not significant)