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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance

Fig. 4

Characterizing 3D spheroid-specific looping genes. A 3D scatterplot showing identified 1678 and 1564 strengthened loop genes in MCF7_3D and MCF7TR_3D, respectively. B Venn diagrams showing 384 of 1678 strengthened looping genes in MCF7_3D as well as 411 of 1564 strengthened looping genes in MCF7TR_3D were differentially expressed between MCF7_3D vs MCF7TR_3D, respectively. C Bar graphs showing the top 10 enriched KEGG pathway and WikiPathway terms for the strengthened looping and differentially expressed genes in MCF7TR_3D. D Patients survival analysis of PRKD3 within a Hippo relevant pathway in ER + breast cancer patients with tamoxifen treatment and without endocrine treatment. Expression levels of PRKD3 gene are classified as low or high (black or red lines, respectively) based on the comparison of its median cut-off value. (E) Patients survival analysis of MET within a Hippo relevant pathway in ER + breast cancer patients with tamoxifen treatment and without endocrine treatment. Expression levels of MET gene are classified as low or high (black or red lines, respectively) based on the comparison of its median cut-off value

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Clinical Epigenetics

ISSN: 1868-7083

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