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Table 3 Epigenome-wide association study results for CpG sites that yielded significant associations after Bonferroni adjustment

From: Prenatal risk factors and neonatal DNA methylation in very preterm infants

CpG

Location

Gene annotation

Coefficient (m-value)

p value (Raw)

p value (Adj)

Coefficienta (beta-value)

Brain-buccal correlation

Model 1: Physical Risk vs. Typical

       

cg25123362

Chr10: 133793734

BNIP3 (Body)

− 0.25

2.76E−11

1.95E−05

− 0.05

− 0.09

Model 1: Psychological Risk vs. Typical

       

cg08930413

Chr7: 151548036

PRKAG2 (Body)

− 0.28

2.11E−08

1.49E−02

− 0.04

0.22

Model 2: Cumulative Prenatal Risk

       

cg16999677

Chr5: 843982

ZDHHC11 (Body)

− 2.05

6.85E−08

4.84E−02

− 0.05

0.61**

cg05324191

Chr1: 116994757

LOC101929023 (Body)

1.03

1.30E−09

9.18E−04

0.02

− 0.33

cg01533736

Chr20: 22542854

LINC00261 (Body)

− 1.18

1.17E−09

8.25E−04

− 0.03

0.40

cg00569188

Chr21: 41122530

IGSF5 (Body)

− 1.28

4.61E−08

3.26E−02

− 0.03

− 0.17

cg09979763

Chr1: 245499904

KIF26B (Body)

− 2.02

4.23E−08

2.99E−02

− 0.03

− 0.07

cg11420269

Chr16: 70516713

COG4 (Body; ExonBnd)

− 1.46

2.07E−08

1.46E−02

− 0.03

0.02

cg27514986

Chr15: 39486981

C15orf54+

2.78

9.74E−09

6.88E−03

0.05

0.19

cg05636131

Chr7: 148844053

ZNF398 (5’ UTR; TSS1500)

− 1.09

6.93E−08

4.90E−02

− 0.02

0.42‡

cg11531492

Chr3: 125673505

ROPN1B+

− 2.63

6.56E−08

4.63E−02

− 0.05

− 0.08

cg26760502

Chr14: 105493800

CDCA4+

− 0.88

4.89E−08

3.45E−02

− 0.01

− 0.09

cg19573457

Chr22: 25893657

CRYBB2P1+

− 1.68

2.17E−08

1.53E−02

− 0.04

0.44*

cg01284858

Chr10: 123902371

TACC2 (5’UTR; Body)

3.61

6.20E−09

4.38E−03

0.06

− 0.32

cg12155575

Chr3: 186965150

MASP1 (Body)

− 1.16

8.97E−09

6.33E−03

− 0.03

0.08

cg11221492

Chr14: 36790270

MBIP (TSS1500)

− 0.90

3.92E−08

2.77E−02

− 0.01

0.54*

cg22102865

Chr7: 148844067

ZNF398 (TSS1500; 5’ UTR)

− 1.24

1.37E−08

9.64E−03

− 0.02

0.46*

  1. aNote that the coefficient for cumulative risk models represents the expected increase in % DNAm associated with a 10% increase in risk. ‡p < .10, *p < .05, **p < .01, + indicates closest gene. Adjusted p-value is Bonferroni corrected