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Table 3 Epigenome-wide association study results for CpG sites that yielded significant associations after Bonferroni adjustment

From: Prenatal risk factors and neonatal DNA methylation in very preterm infants

CpG Location Gene annotation Coefficient (m-value) p value (Raw) p value (Adj) Coefficienta (beta-value) Brain-buccal correlation
Model 1: Physical Risk vs. Typical        
cg25123362 Chr10: 133793734 BNIP3 (Body) − 0.25 2.76E−11 1.95E−05 − 0.05 − 0.09
Model 1: Psychological Risk vs. Typical        
cg08930413 Chr7: 151548036 PRKAG2 (Body) − 0.28 2.11E−08 1.49E−02 − 0.04 0.22
Model 2: Cumulative Prenatal Risk        
cg16999677 Chr5: 843982 ZDHHC11 (Body) − 2.05 6.85E−08 4.84E−02 − 0.05 0.61**
cg05324191 Chr1: 116994757 LOC101929023 (Body) 1.03 1.30E−09 9.18E−04 0.02 − 0.33
cg01533736 Chr20: 22542854 LINC00261 (Body) − 1.18 1.17E−09 8.25E−04 − 0.03 0.40
cg00569188 Chr21: 41122530 IGSF5 (Body) − 1.28 4.61E−08 3.26E−02 − 0.03 − 0.17
cg09979763 Chr1: 245499904 KIF26B (Body) − 2.02 4.23E−08 2.99E−02 − 0.03 − 0.07
cg11420269 Chr16: 70516713 COG4 (Body; ExonBnd) − 1.46 2.07E−08 1.46E−02 − 0.03 0.02
cg27514986 Chr15: 39486981 C15orf54+ 2.78 9.74E−09 6.88E−03 0.05 0.19
cg05636131 Chr7: 148844053 ZNF398 (5’ UTR; TSS1500) − 1.09 6.93E−08 4.90E−02 − 0.02 0.42
cg11531492 Chr3: 125673505 ROPN1B+ − 2.63 6.56E−08 4.63E−02 − 0.05 − 0.08
cg26760502 Chr14: 105493800 CDCA4+ − 0.88 4.89E−08 3.45E−02 − 0.01 − 0.09
cg19573457 Chr22: 25893657 CRYBB2P1+ − 1.68 2.17E−08 1.53E−02 − 0.04 0.44*
cg01284858 Chr10: 123902371 TACC2 (5’UTR; Body) 3.61 6.20E−09 4.38E−03 0.06 − 0.32
cg12155575 Chr3: 186965150 MASP1 (Body) − 1.16 8.97E−09 6.33E−03 − 0.03 0.08
cg11221492 Chr14: 36790270 MBIP (TSS1500) − 0.90 3.92E−08 2.77E−02 − 0.01 0.54*
cg22102865 Chr7: 148844067 ZNF398 (TSS1500; 5’ UTR) − 1.24 1.37E−08 9.64E−03 − 0.02 0.46*
  1. aNote that the coefficient for cumulative risk models represents the expected increase in % DNAm associated with a 10% increase in risk. p < .10, *p < .05, **p < .01, + indicates closest gene. Adjusted p-value is Bonferroni corrected