Fig. 3

Cross-lagged panel analysis (CLPM) of BMI-associated methylation risk score (MRS) and IL-6. Pathway coefficients and corresponding P-values are provided. Unidirectional arrows indicate regression, and bidirectional arrows indicate correlation. Arrows with red numbers indicate significant pathway coefficients (P-value < 0.05), and arrows with black numbers indicate nonsignificant pathway coefficients. The pathways coefficient from baseline MRS to follow-up IL-6 is significant (P-value = 0.027)