Table 1 Bonferroni significant DMCs in vitamin C smokers versus placebo (VP) and in placebo versus never-smokers (PN)
Probe | Comparison | Location | Nearest gene | Distance to nearest gene (Kbp) | Bonferroni significant EWAS results* | ||
|---|---|---|---|---|---|---|---|
Delta beta | P value | Bonferroni adj. P value | |||||
cg20790161 | VP | chr2:204553666 | CD28 | 17.5 | − 0.16 | 1.63E−12 | 1.16E−06 |
– | – | – | – | – | – | – | – |
cg27402634 | PN | chr3:156536860 | LINC00886 | 2.0 | − 0.31 | 7.53E−31 | 5.38E−25 |
cg20385913 | PN | chr15:75054510 | CYP1A2 | 13.3 | 0.08 | 5.91E−17 | 4.22E−11 |
cg21702971 | PN | chr12:57588243 | LRP1 | 66.0 | 0.03 | 3.66E−13 | 2.61E−07 |
cg04895640 | PN | chr1:36807418 | STK40 | 19.5 | 0.02 | 3.85E−10 | 2.75E−04 |
cg12026561 | PN | chr11:122238873 | MIR100HG | 12.9 | − 0.04 | 4.78E−10 | 3.42E−04 |
cg03313447 | PN | chr19:41829042 | CCDC97 | 0.4 | − 0.05 | 5.14E−10 | 3.68E−04 |
cg25639387 | PN | chr7:149503093 | SSPO | 30.0 | − 0.04 | 1.32E−09 | 9.47E−04 |
cg03256631 | PN | chr3:98445144 | ST3GAL6-AS1 | 6.4 | − 0.07 | 1.64E−09 | 1.17E−03 |
cg21362410 | PN | chr11:63650618 | MARK2 | 44.2 | 0.04 | 2.59E−09 | 1.85E−03 |
cg07752120 | PN | chr5:70746259 | BDP1 | 5.2 | − 0.02 | 4.67E−09 | 3.34E−03 |
cg24797066 | PN | chr20:48407084 | SLC9A8 | 22.2 | − 0.07 | 1.08E−08 | 7.73E−03 |
cg24372191 | PN | chr15:48116584 | SEMA6D | 105.9 | 0.06 | 1.50E−08 | 1.07E−02 |
cg04572941 | PN | chr3:110033667 | NECTIN3-AS1 | 755.1 | − 0.04 | 3.06E−08 | 2.18E−02 |
cg10563109 | PN | chr6:5087749 | PPP1R3G | 2.0 | 0.02 | 3.49E−08 | 2.49E−02 |
cg14015502 | PN | chr10:104535020 | WBP1L | 31.3 | − 0.08 | 3.77E−08 | 2.69E−02 |
cg00376466 | PN | chr1:14463622 | PRDM2 | 387.8 | − 0.08 | 4.39E−08 | 3.14E−02 |
cg24034752 | PN | chr20:36023689 | SRC | 49.1 | − 0.04 | 5.95E−08 | 4.25E−02 |