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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Fig. 3

Gene expression changes in HMCLs upon genetic or pharmacological inhibition of SETD8. a Diagram of the experimental plan. b Molecular signatures of UNC-0379 and shSETD8 downregulated (blue bar plot) and up-regulated (red bar plot) genes compared to control were investigated using GSEA Database (all curated gene sets), and relevant pathways are presented (FDR q value ≤ 0.05). c Immunoblot analysis of indicated proteins in total lysates from UNC-0379-treated or untreated XG7 HMCL. β-actin and H2A.X were used as loading controls

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Clinical Epigenetics

ISSN: 1868-7083

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