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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Fig. 1

SETD8 expression is a prognosis value in MM. a SETD8 gene expression in BMPCs, patients’ MMCs and HMCLs. Data are MAS5-normalized Affymetrix signals (U133 plus 2.0 microarrays). Statistical difference was assayed using a student t test. b Immunoblot analysis of indicated proteins in total lysates from normal plasma cells, MMCs and HMCLs (XG1, XG7, XG25). β-actin and histone H4 were used as loading controls. c Overall survival and of newly diagnosed MM patients (UAMS-TT2, N = 345; and UAMS-TT3, N = 158) who’s MMCs highly expressed SETD8 gene. The splitting of the patients into two groups according to SETD8 expression in MMCs was done using the Maxstat algorithm

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Clinical Epigenetics

ISSN: 1868-7083

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