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Fig. 6 | Clinical Epigenetics

Fig. 6

From: METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors

Fig. 6

METTL3 depletion cooperates with cisplatin or JQ1 inhibitor in the induction of cell death. AB Cell counting analysis by trypan blue exclusion (left) and cytofluorimetric analysis (right), after 48 h of treatment with CDDP (A) or JQ1 (B), in control (siC) and METTL3-silenced (siMETTL3) TC1889 cells, n = 3. C Representative Western blot analysis of METTL3 and c-MYC proteins in cells treated as in (B, B). See also Additional file 5: Fig. S5 for quantifications. *p ≤ 0.05; **p ≤ 0.005; ***p ≤ 0.0005; ****p ≤ 0.00005; p-values have been calculated by One-Way Anova

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