DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker

Table 2 Cox proportional hazard models of survival by RPMM 5hmC cluster membership

A			B
Cox proportional hazard ratios for survival^a			Cox proportional hazard ratios for recurrence^b
Variable	HR (95% CI)	P value	Variable	HR (95% CI)	P value
Age	0.97 (0.83–1.1)	0.70	Age	0.93 (0.80–1.1)	0.30
Sex			Sex
Female	1.0 (referent)		Female	1.0 (referent)
Male	0.73 (0.12–4.3)	0.73	Male	0.70 (0.20–2.4)	0.58
Tumor type			Tumor type
Glioma	1.0 (referent)		Glioma	1.0 (referent)
Ependymoma	3.93 (0.54–28.6)	0.18	Ependymoma	6.63(1.21 -36.3)	0.03
Embryonal	4.95 (0.63 -38.9)	0.13	Embryonal	4.27 (0.76 -24.1)	0.10
RPMM cluster			RPMM cluster
High 5hmC cluster	1.0 (referent)		High 5hmC cluster	1.0 (referent)
Low 5hmC cluster	6.47 (0.79–53.2)	0.08	Low 5hmC cluster	4.83 (0.95–24.6)	0.06

^aMultivariate Cox proportional hazard ratios and confidence interval for survival based on RPMM cluster membership adjusted for age, sex, and tumor type demonstrated an increased hazard of death for the low 5hmC RPMM cluster (HR 6.47, 95% CI 0.79–53.2, P = 0.08)
^bMultivariate cox proportional hazard ratio for recurrence based on RPMM cluster membership adjusting for age, sex, and tumor type demonstrated an increased hazard of recurrence for the low 5hmC cluster (HR 4.83, 95% CI 0.95–24.6, P = 0.06)

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