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Fig. 5 | Clinical Epigenetics

Fig. 5

From: DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker

Fig. 5

Results from linear models comparing CpG hydroxymethylation in each tumor subtype to non-tumors. Blue represents loss of 5hmC and red gain of 5hmC by tumor as compared to controls. a Volcano plot of differentially hydroxymethylated regions in a comparison between embryonal and control samples. Colored points represent CpGs that are differentially hydroxymethylated with an adjusted P value (FDR) less than 0.1. 15,072 CpGs of the 37,173 high 5hmC CpGs were significantly differentially hydroxymethylated with an FDR less than 0.1. b Volcano plot comparing ependymomas to non-tumors. Colored points represent an FDR less than 0.1. c Comparison of gliomas to controls. No points reached statistical significance

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Clinical Epigenetics

ISSN: 1868-7083

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