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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

Fig. 2

Molecular regulatory mechanisms of DNMT inhibitors in increasing the sensitivity to drugs. DNMT inhibitor treatment can increase the sensitivity of chemotherapeutic drugs via the methylation status of ARNTL, RASS1, MLH1, hMLH1, WT1 and BCL-2. DNMT inhibitors are able to sensitize tumor-targeting drugs through the induction of various proteins, such as EREG, EGFR and XAF1. They can also enhance immunotherapy by targeting EZH2 and MAGE-3

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Clinical Epigenetics

ISSN: 1868-7083

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