Skip to main content
Fig. 2 | Clinical Epigenetics

Fig. 2

From: Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation

Fig. 2

Genomic region of TBS in FKBP5 and methylation structure. Different transcripts of FKBP5 (a). Genomic positions of TBS amplicons (b) and FKBP5 SNP rs1360780 (c). Mean methylation level of all samples across FKBP5 amplicons (d). Mean difference of methylation level between groups per amplicon. A negative value indicates that individuals administered with betamethasone (BET) present with lower methylation levels than control subjects (e). Position of functional regions (f). Boxplot for association of methylation with BET. The x-axis denotes the BET exposure group, depicted in purple, and the control group, depicted in yellow. The y-axis denotes methylation level in the intronic glucocorticoid response elements (GRE) of intron 7 (g). Boxplot for association of rs1360780 and methylation. The x-axis denotes the genotype. The y-axis denotes the methylation level at PCR_12_47 in the intronic GRE of intron 1 (h). Boxplot for the interaction of rs1360780 and BET on methylation. The x-axis denotes the combination of genotype and BET, e.g. ‘BET.CC’ indicates the group presenting with BET and a CC genotype while ‘no BET.CT’ indicates the group with no BET exposure and the CT genotype. The y-axis denotes methylation level at PCR_3_in the intronic GRE of intron 5 (i)

Back to article page