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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque

Fig. 2

The genome-wide signature of DNA methylome in SYM and ASYM plaques. a Circos graph of DNA methylation levels in atherosclerotic SYM plaques (n = 6) in comparison with ASYM plaques (n = 8). The outer circle displays human chromosomes with scale at 1 MB bins. The hypomethylation probes are displayed as green lines, and hypermethylation probes are displayed as red lines. The height of the blue background indicates the scale of beta-scores in DNA methylation assays. b Hypo- and hypermethylated in SYM plaques compared with ASYM plaques are displayed on the left and right panels, respectively. The blue pie charts display the relative distribution of differential hypo- and hyper-methylated regions in promoters, gene bodies, 3'-UTRs, and intergenic regions. The red pie charts display the relative distribution of differential hypo-and hypermethylated regions in CpG islands, shore, shelf, and open sea regions. SYM, symptomatic; and ASYM, asymptomatic

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