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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain

Fig. 6

Early pre-implantation ethanol exposure leads to partial loss of DNA methylation maintenance across imprinting control regions. a-c Heatmaps representing CpG methylation levels for control versus EtOH-exposed samples in regions (100 bp tiles) located within defined imprinting control regions. Examples of CpG methylation levels of individual samples in imprinting control regions associated tiles are shown. ǂ represents significant differences in CpG methylation levels of DMRs (e.g., ±  > 10% methylation difference, q < 0.01) between control and EtOH-exposed embryos (see methods section for details). a Imprinting control regions (n = 28 tiles) analyzed (sufficient sequencing coverage) in both male and female samples (control vs EtOH-exposed). b Imprinting control regions (n = 13 tiles) analyzed only in males (lack of proper sequencing coverage in females). c Imprinting control regions (n = 36 tiles) analyzed only in females (lack of proper sequencing coverage in males)

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