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Table 2 A description of the methodology used to derive each epigenetic clock employed in the current study

From: Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

Clock Classification Normalization approach CpG availability Derivation method
Hannum [16] Age-trained Noob [57] 65 of 71 R software: ENmix (methyAge function) [64]
Horvath [15] Age-trained Noob [57] 334 of 353 Online software: http://dnamage.genetics.ucla.edu/
Lin [30] Age-trained Preprocessillumina [57] 97 of 99 Used published weights [30]
Yang [31] Mitotic clock BMIQ [65] 354 of 385 R software [31]
Dunedin PoAm [20] Phenotype BMIQ [65] 46 of 46 R software: DunedinPoAm38 [20]
GrimAge [22] Phenotype/mortality Noob [57] 1030 of 1030* Online software: http://dnamage.genetics.ucla.edu/
PhenoAge [21] Phenotype/mortality Noob [57] 513 of 513 Online software: http://dnamage.genetics.ucla.edu/
Zhang [32] Mortality Preprocessillumina [57] 8 of 10 Used published weights [32]
  1. *GrimAge CpGs have not been released, so the availability of sites for the current study is assumed given that the algorithm was designed to be compatible with the EPIC 850 K array [22]