Fig. 5

Characterization of the 13 differentially expressed DMR-associated genes between CTR and CZ patients. a Line plots showing the expression along the latent time of the 11 DMR associated differentially expressed genes in CTR (teal) and CZ (purple) dataset determined by tradeSeq analysis. The dashed lines mark the knots dividing the three knot groups. The grey areas identify the knot groups in which statistical significance is reached for each gene. Values can be found in Additional file 1: Table S11. b Box plots showing the average expression values of the DMR-associated genes that resulted to be differentially expressed using MAST while comparing the CTR (teal, n = 3) and CZ scRNA-seq datasets (purple, n = 3). Values can be found in Additional file 1: Table S12