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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes

Fig. 2

CTR-CZ DMRs are associated with 132 genes. a Global comparison of methylomes from control (CTR) and cryptozoospermic (CZ) testicular germ cells. PCA generated for ca. 20 million CpG loci where all samples show methylation values. Only loci with minimum coverage of five in all samples and minimum mapping quality of 10 are considered. CTR testicular germ cell samples in teal, CZ samples in purple. b Cluster analysis of the methylation values for the 271 CTR-CZ DMRs in the eight TGC samples. c Enrichment/depletion of DMRs for functional genomic regions. LMR, low-methylated region; UMR, unmethylated regions; CGI, CpG islands. d DMRs are associated with 132 genes by overlapping genes, promoters and/or “double-elite” enhancers (GeneHancer)

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Clinical Epigenetics

ISSN: 1868-7083

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