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Fig. 6 | Clinical Epigenetics

Fig. 6

From: A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease

Fig. 6

Correlation between PON1 variability and waist-to-hip ratio. The graph represents the combined (epi)genetic relationship between rs705379:C > T and average promoter methylation on waist-to-hip ratio in a population of patients with a wide range of (hepato)metabolic derangements. Average promoter methylation is displayed as methylation M-values on the x-axis and waist-to-hip ratios on the y-axis. The three different screens in the graph illustrate the genotypes of rs705379:C > T. A total of 45 liver biopsies were analysed for which genotype distribution over PON1 rs705379:C > T is 27% CC, 58% CT and 15% TT. Methylation is represented as M-values; positive M-values mean that more molecules are methylated than unmethylated (> 50% methylation) while negative M-values mean the opposite (< 50% methylation)

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