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Fig. 1 | Clinical Epigenetics

Fig. 1

From: A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease

Fig. 1

Relationship between PON1 genetics and substrate-specific enzymatic activity. The different boxplots indicate the relationship between each genotype of the three common PON1 polymorphisms rs705379:C > T, rs854560:A > T, rs662:T > C on serum lactonase (a) and arylesterase (b) in a population of patients with a wide range of (hepato)metabolic derangements. A total of 714 serum samples were analysed for which genotype distribution over the three PON1 variants is as follows: 26% CC, 46% CT and 28% TT for rs705379:C > T; 16% TT, 46% AT and 38% AA for rs854560:A > T; and 50% TT, 41% CT and 9% CC for rs662:T > C. Activity levels are expressed as units per millilitre of serum, in which 1 unit equals 1 mmol of 5-thiobutyl butyrolactone (lactone-hydrolysing activity) or phenyl acetate (arylester-hydrolysing activity) hydrolysed/min. The significance level (p) and FDR threshold (q) were set at 0.05

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Clinical Epigenetics

ISSN: 1868-7083

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