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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology

Fig. 2

Chromatin loop formation in GSC differentiation. GSCs present a more relaxed and accessible chromatin state with permissive interactions between enhancers and promoters among different domains. During GSC differentiation, loss of stemness in non-stem glioma cells (NSGC) correlates with increased chromatin-loop formation, adopting a more restricted chromatin conformation with strong domain boundaries and limited enhancer–promoter interactions

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Clinical Epigenetics

ISSN: 1868-7083

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