Fig. 1

Genome wide methylation patterns of ACD/MPV lung tissues suggest abnormal gene regulation. a Hypermethylated (red) and hypomethylated (blue) regions in ACD/MPV lungs that were found genome wide (X- and Y-chromosome excluded; fold change < 2 excluded). The bar height indicates the relative fold change (FC) of the differentially methylated regions (DMRs). b Pie chart of the distribution of hyper- (red) and hypomethylated (blue) DMRs. c Results of gene ontology cluster enrichment analyses with Metascape [26] using the lists of genes that are potentially up- and downregulated based on the overlap of DMRs with promoters and gene bodies (squares with pie slices on the left indicate DMR overlap) (Additional file 1: table S 1)