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Table 2 The methylated genes and ovarian cancer multidrug resistance in the literature

From: Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer

Author Year N Population Gene Tissue Methods Cell Methylation level in chemoresistant tissue/cell Expression Drugs References
Strathdee 2005 41 UK MCJ Advanced EOC Bisulfite sequencing Hypermethylation Downregulation Cisplatin [24]
Lee 2009 61 UK MAL SOC Bisulfite sequencing Hypomethylation Upregulation Platinum [25]
Watanabe/Gifford 2007/2004 36/138 Japan/UK hMLH1 Advanced EOC MSP Hypermethylation Downregulation Platinum [26, 27]
Wang 2010 BRCA1 Bisulfite sequencing COC1/COC1CisR Hypomethylation Upregulation Cisplatin [28]
Chou 2010 96 China FBXO32 OC MSP Hypermethylation Downregulation Cisplatin [29]
Nicholson 2009 54 UK ASS1 EOC Bisulfite sequencing Hypermethylation Downregulation Cisplatin [63]
GAO 2019 RASSF1A MSP A2780/A2780CisR Hypermethylation Downregulation Cisplatin [31]
GAO 2019 MDR1 MSP A2780/A2780CisR Hypomethylation Upregulation Cisplatin [31]
Dai 2012 PTEN Bisulfite sequencing OVCAR3 Hypermethylation Downregulation Taxol [32]
Li 2009 DR4 MSP 2008, Hey, NMP-1, OVCAR3, SKOV3, A2780 Hypermethylation Downregulation Platinum [33]
Bram 2009 ABCG2 COBRA IGROV1 Hypomethylation Upregulation Platinum [34]
Chiang 2013 136 China BLU Advanced HGSOC MSP SKOV3, OVCAR3 Hypermethylation Downregulation Platinum [35]
Wang 2012 40 China TGFBI EOC MSP SKOV3/SKOV3CisR, SKOV3/TR, A2780/TR Hypermethylation Downregulation Cisplatin and palitaxel [36]
Ali 2013 RGS10 Bisulfite sequencing A2780/A2780CisR, CAOV3, SKOV3 Hypermethylation Downregulation Cisplatin [37]
Okochi-Takada 2006 17 Japan UCHL1 OC MSP 13 ovarian cancer cell lines Hypermethylation Downregulation Cisplatin [38]
Staub 2007 HSulf-1 MSP SKOV3, OV207 Hypermethylation Downregulation Platinum [39]
Su 2010 126 China SFRP5 EOC MSP Hypermethylation Downregulation Cisplatin [40]
IZUTSU 2008 66 Japan TUBB3 OC Bisulfite sequencing OVCAR-3, JHOC-8 Hypomethylation Upregulation Paclitaxel [41]
Pattamadilok 2008 59 Thailand LINE-1 EOC COBRA Hypomethylation Unknown Platinum [42]
Jiang 2014 HOXA10 MSP SKOV3, HEY Hypomethylation Upregulation Platinum [43]
Matei 2012 17 America HOXA9, HOXA11 OC Genome-wide methylation study Hypermethylation Unknown Platinum [44]
Taniguchi 2003 19 America FANCF OC MSP Hypomethylation Upregulation Cisplatin [45]
YANG 2018 OXCT1 Genome-wide methylation study 8 ovarian cancer cell lines Hypermethylation Downregulation Cisplatin [46]
Zhao 2021 483 GEO and TCGA AGR2, HSPA2, ACAT2 SOC Genome-wide methylation study Hypermethylation Unknown Platinum [47]
Pan 2017 SERPINE1 MassArray EpiTYPER A2780CP Hypomethylation Upregulation Carboplatin [9]
Zeller 2012 ARMCX2, COL1A1, MDK, MEST Genome-wide methylation study A2780CisR Hypermethylation Downregulation Cisplatin [48]
Ha 2018 NAGA Genome-wide methylation study 11 ovarian cancer cell lines Hypermethylation Downregulation Cisplatin [49]
Visco 2021 16 America CLDN1 Advanced SOC Genome-wide methylation study Hypomethylation Upregulation Cisplatin [50]
Bonito 2016 61 UK MSX1 HGSOC Genome-wide methylation study Hypomethylation Upregulation Platinum [51]
Tomar 2016 CSK HGSOC PDXs Genome-wide methylation study Hypermethylation Downregulation Platinum [52]
Fang 2018 120 USA DOK2 OC Genome-wide methylation study OVCAR3, SKOV3 Hypermethylation Downregulation Platinum [53]
Yu 2011 PTK6, PRKCE, BCL2L1 Genome-wide methylation study A2780CisR Hypomethylation Upregulation Cisplatin [54]
Teschendorff 2015 134 UK HOTAIR OC Genome-wide methylation study Hypomethylation Upregulation Platinum [55]
Tian 2019 16 China hMSH2 EOC Bisulfite sequencing Hypermethylation Downregulation Platinum [15]
Syed 2011 52 Germany Plk2 EOC MSP A2780CisR, SKOV3CisR Hypermethylation Downregulation Cisplatin [56]
Leon 2016 TMEM88 OC xenografts Genome-wide methylation study Hypomethylation Upregulation Platinum [57]
Mase 2019 78 Japan/China ZNF671 HGSOC Genome-wide methylation study JHOS2/4, OVCAR3 Hypermethylation Downregulation Platinum [58]
Baba 2009 CD133/PROM1 MSP OVCAR8/432, A2780, PEO1 Hypomethylation Upregulation Platinum [59]
Shang/Litkouhi 2013/2007 CLDN4 MSP 2008 Hypermethylation Downregulation Cisplatin [60, 61]
Witham 2008 DNAJC15 Bisulfite sequencing OVCAR3/4/5/8, SKOV3 Hypermethylation Downregulation Platinum [62]
Kritsch 2017 TRIB2 Genome-wide methylation study A2780CisR, SKOV3CisR Hypermethylation Downregulation Cisplatin [10]
Lund 2017 KLF4 Genome-wide methylation study M019iCisR, OC002CisR Hypermethylation Downregulation Cisplatin [11]
Tomar 2017 45 Netherlands FZD10 HGSOC Genome-wide methylation study 10 ovarian cancer cell lines Hypomethylation Upregulation Platinum [12]
Vaclavikova 2019 61 Czech Republic ABCB1 EOC Bisulfite sequencing Hypomethylation Upregulation Platinum [63]
Yao/Duan 2004/1999 TRAG-3/CSAG2 COBRA SKOV3 Hypomethylation Upregulation Taxol [30, 65]
  1. EOC epithelial ovarian cancer, SOC serous ovarian cancer, HGSOC high-grade serous ovarian cancer, MSP methylation-specific polymerase chain reaction, COBRA combined bisulfite restriction analysis, CisR cisplatin resistant, TR palitaxel resistant, CP carboplatin resistant