Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD

Clinical Epigenetics

Table 2 Summary information for seven CpGs associated with fibrosis

CpG	Chr	Position	Effect size	T-stat	p val	Overlapping gene	Enhancer ID	Genes linked to enhancer
cg09822959	6	82,862,789	− 0.159	− 5.4	5.93E−08		GH06F082862	LOC105377877, GC06M082916
cg19686543	7	148,327,678	− 0.093	− 6.0	1.87E−09	CNTNAP2	None	N/A
cg08033828	9	89,137,984	− 0.093	− 5.6	2.61E−08	SHC3	GH09F089136	SHC3, CKS2
cg05550145	10	71,871,455	− 0.174	− 5.7	1.08E−08		GH10F071871	VSIR, PSAP
cg09998038	10	73,894,805	− 0.052	− 5.5	3.99E−08		GH10F073886	NDST2, KAT6B, C10orf55, DNAJC9, FUT11, VCL, MYOZ1, CAMK2G, SEC24C, DUSP8P5, ANXA7, PLAU
cg22317887	17	37,698,375	− 0.067	− 5.7	1.17E−08	HNF1B	GH17F037697	HNF1B, MRPL45, LOC105371754, GC17P037657
cg01931861	21	41,601,636	− 0.077	− 5.6	2.22E−08		GH21F041601	LOC105372809, LOC105372812

ISSN: 1868-7083