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Table 1 Linear mixed/fixed effect regression models used in the secondary analyses

From: DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury

Model

Function

Response

Predictors

Fixed effect

Random effect

Model (a)

Test pmTBI versus HC difference of clinical/cognitive variables

A clinical or cognitive variable

Diagnosis (pmTBI/HC), age, sex, BMI, race

Family ID

Model (b)

Test pmTBI versus HC difference of methylation features

Loadings of a methylation component or a CpG site in BDNF/APOE4

Diagnosis (pmTBI/HC), age, sex, BMI, race, buccal cell proportion, PC 2–4

Family ID

Model (c)

Test the association between methylation features and PCSI/PedsQL/depression symptom score at EC within pmTBI patients

Global methylation or loadings of a methylation component or a CpG site in BDNF/APOE4

PCSI/PedsQL/depression symptom score at EC, age, sex, BMI, race, buccal cell proportion, PC 2–4

N/A

Model (d)

Test the association between depression symptom at SA/EC and loadings of 30 methylation components within pmTBI patients

Depression symptom at SA/EC

Loadings of 30 methylation components, age, sex, BMI, race

N/A

  1. BMI represents body mass index. N/A denotes not available (same for Tables 2 and 3)
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Clinical Epigenetics

ISSN: 1868-7083

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