Fig. 2
From: The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Histone H3K4me3 interactome. A KMT2F/G (SETD1A/B) are recruited via CXXC1 (CFP1) subunit to CpG islands. CBP/p300, which acetylates H3K27, binds to KMT2F/G. The H3K4me3-modified nucleosomes bind to multiple readers (CHD1, TAF3, ING, U2AF65, U2 snRNP, PAF, FACT, and KATs). KDM5 family members (erasers) are associated with HDAC1 and 2. The sequence of the first 34 amino acids of H3.3 is identical to the other H3s, except at amino acid position 31. B The broad epigenetic domain of the GATA3 gene in MCF7 breast cancer cells. ChIP-Seq (H3K4me3, H3K27ac, CHD1) and DNase-seq tracks at the GATA3 gene are shown [80]. Me2s, symmetric dimethylation, Ac, acetylation