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Table 4 Association between DNA methylation and behavior reports in individuals with 49,XXXXY

From: DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study

 

CBCL total problems (95% CI)

P value

CBCL externalizing problems (95% CI)

P value

CBCL internalizing problems (95% CI)

P value

MAOA CpG-1

0.32 (− 0.03, 0.67)

0.08

0.30 (− 0.03, 0.62)

0.08

0.32 (− 0.09, 0.73)

0.13

MAOA CpG-2

0.27 (0.0002, 0.54)

0.06

0.31 (0.07, 0.55)

0.02

0.16 (− 0.16, 0.49)

0.33

MAOA CpG-3

0.33 (− 0.07, 0.73)

0.12

0.40 (0.04, 0.76)

0.04

0.23 (− 0.24, 0.70)

0.35

MAOA CpG-4

0.25 (− 0.06, 0.56)

0.13

0.32 (0.04, 0.60)

0.03

0.12 (− 0.25, 0.50)

0.52

MAOA CpG-5

0.20 (− 0.07, 0.47)

0.17

0.24 (− 0.004, 0.49)

0.06

0.15 (− 0.17, 0.47)

0.38

MAOA CpG-6

0.22 (− 0.07, 0.50)

0.15

0.26 (− 0.001, 0.52)

0.06

0.15 (− 0.18, 0.49)

0.38

MAOA CpG-7

0.22 (− 0.02, 0.45)

0.08

0.27 (0.06, 0.47)

0.02

0.13 (− 0.15, 0.40)

0.38

AR CpG-1

0.99 (− 0.14, 1.84)

0.07

1.05 (− 0.002, 2.11)

0.11

0.56 (− 0.28, 1.41)

0.25

AR CpG-2

1.33 (− 0.10, 2.57)

0.09

1.38 (− 0.16, 2.92)

0.14

0.71 (− 0.51, 1.93)

0.31

AR CpG-3

0.36 (− 0.44, 1.16)

0.42

0.32 (− 0.63, 1.26)

0.54

0.19 (− 0.48, 0.86)

0.61

AR CpG-4

1.16 (− 0.46, 2.78)

0.22

1.13 (− 0.84, 3.09)

0.31

0.68 (− 0.74, 2.10)

0.39

 

BRIEF Behavioral Regulation Index (95% CI)

P value

BRIEF Metacognition Index (95% CI)

P value

BRIEF Global Executive Composite (95% CI)

P value

MAOA CpG-1

0.23 (− 0.23, 0.68)

0.33

0.05 (− 0.32, 0.42)

0.80

0.10 (− 0.30, 0.50)

0.63

MAOA CpG-2

0.23 (− 0.14, 0.60)

0.24

0.03 (− 0.28, 0.33)

0.86

0.09 (− 0.24, 0.41)

0.60

MAOA CpG-3

0.25 (− 0.30, 0.79)

0.39

0.06 (− 0.39, 0.50)

0.81

0.11 (− 0.36, 0.59)

0.65

MAOA CpG-4

0.31 (− 0.11, 0.74)

0.16

0.03 (− 0.33, 0.39)

0.87

0.12 (− 0.26, 0.50)

0.54

MAOA CpG-5

0.10 (− 0.26, 0.47)

0.58

− 0.02 (− 0.32, 0.27)

0.88

0.01 (− 0.31, 0.32)

0.97

MAOA CpG-6

0.21 (− 0.17, 0.59)

0.29

0.03 (− 0.28, 0.35)

0.85

0.08 (− 0.26, 0.42)

0.65

MAOA CpG-7

0.18 (− 0.14, 0.51)

0.28

0.02 (− 0.25, 0.28)

0.90

0.07 (− 0.22, 0.35)

0.66

AR CpG-1

1.59 (0.63, 2.54)

0.03

0.97 (0.14, 1.80)

0.08

1.11 (− 0.06, 2.28)

0.13

AR CpG-2

1.99 (0.41, 3.58)

0.07

1.22 (− 0.05, 2.48)

0.13

1.40 (− 0.32, 3.12)

0.19

AR CpG-3

0.69 (− 0.40, 1.79)

0.28

0.45 (− 0.33, 1.22)

0.32

0.42 (− 0.63, 1.47)

0.48

AR CpG-4

2.17 (0.26, 4.07)

0.09

1.55 (0.30, 2.80)

0.07

1.55 (− 0.44, 3.53)

0.20

  1. The P value threshold for statistical significance after Bonferroni correction for the number of CpG sites tested was 0.005