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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study

Fig. 2

X chromosome number-dependent increase in MAOA methylation levels in 46,XY; 47,XXY; 48,XXXY+; and 49,XXXXY individuals. Bisulfite pyrosequencing of saliva DNA shows a dose-dependent increase in DNA methylation in intron 1 of the MAOA gene (a). Linear regression analysis for CpG-1 showed a strong correlation between observed DNA methylation and X chromosome number (b). The 48,XXXY + group consists of two individuals with 48,XXXY and one with 49,XXXYY karyotype. Groups with different numbers of X chromosomes (1–4) are: 46,XY; 47,XXY; 48,XXXY + ; and 49,XXXXY, respectively. Error bars are presented as mean ± STD

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