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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers

Fig. 2

K-means clustering of transcriptome data. (A) K-means was used to define 10 groups of genes with similar profiles (k = 10, 100 rounds, correlation distance). (B) Boxes represent mean profiles of a given cluster. Yellow star means profile significantly different from normal samples (N). Significance was calculated with a student test between the group tested and the normal group, with a Bonferroni correction for multitesting. N: Normal, E: Exposed, C: Contralateral, T: tumor. (C) Top-10 annotations of significant clusters and exemplary genes. Clusters were subjected to functional annotations of Gene Ontology using GOminer. GO_ID refers to Gene Ontology unique identifier and Term refers to Term name. Molecular Function, Cellular Component and Biological Process wee pooled together. Enrichment refer to Observed/Expected frequency of GO term. FDR is the corrected p-value calculated by bootstrap. A FDR of 0 means inferior to 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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