Fig. 3

Methylation status at the promoter region of 32 escape genes examined by array-based methylation analysis using the Illumina Infinium Human Methylation EPIC BeadChip kit in the four patients. The heat map of β values in the four patients. The probes with lower than 0.25 in the β value are shown in gray and those with higher methylation (over 0.25) are shown in pink. The names of escape genes are shown at the right side of the heat map. The names of the three genes with abnormal methylation in Patient 1 are exhibited in red. The number of probes in each gene is shown as the height of each gene in the heat map (the height of one probe and two probes is exemplified at the lower right part of the figure)