Skip to main content

Table 3 Univariate and multivariate Cox regression survival analysis of MCA cluster and other characteristics of interest, in relation to cancer-specific survival after androgen-deprivation therapy

From: A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

 

P

RR

95% CI

Univariate

 MCA cluster (negative vs. positive, n = 25 and 41)

0.0016

2.4

1.4–4.1

 AR score

0.35

0.9

0.8–1.1

 Prol. score

0.039

1.1

1.0–1.1

 AR (ampl. vs. WT, n = 24 and 42)

0.12

1.5

0.9–2.6

 Age (at metastsis surgery)

0.42

1.0

1.0–1.0

 Metastasis subtype#

  MetA (n = 46)

 

1.0

 

  MetB (n = 12)

0.034

2.0

1.1–3.9

  MetC (n = 8)

0.95

0.98

0.45–2.1

 Serum PSA (at metastasis surgery)

0.07

1.0

1.0–1.0

Multivariate

 MCA cluster (negative vs. positive, n = 25 and 41)

0.0017

2.7

1.5–5.1

 Prol. score

0.89

0.99

0.90–1.1

 Metastasis subtype

 

1.0

 

  MetA (n = 46)

 

1.6

0.52–5.2

  MetB (n = 12)

0.40

0.58

0.25–1.3

  MetC (n = 8)

0.20

  
  1. Variables with a P-value below 0.05 (shown in bold) in univariate survival analysis were taken further into multivariate analysis
  2. #Metastasis subtypes according to [12]