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Table 3 Univariate and multivariate Cox regression survival analysis of MCA cluster and other characteristics of interest, in relation to cancer-specific survival after androgen-deprivation therapy

From: A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

  P RR 95% CI
Univariate
 MCA cluster (negative vs. positive, n = 25 and 41) 0.0016 2.4 1.4–4.1
 AR score 0.35 0.9 0.8–1.1
 Prol. score 0.039 1.1 1.0–1.1
 AR (ampl. vs. WT, n = 24 and 42) 0.12 1.5 0.9–2.6
 Age (at metastsis surgery) 0.42 1.0 1.0–1.0
 Metastasis subtype#
  MetA (n = 46)   1.0  
  MetB (n = 12) 0.034 2.0 1.1–3.9
  MetC (n = 8) 0.95 0.98 0.45–2.1
 Serum PSA (at metastasis surgery) 0.07 1.0 1.0–1.0
Multivariate
 MCA cluster (negative vs. positive, n = 25 and 41) 0.0017 2.7 1.5–5.1
 Prol. score 0.89 0.99 0.90–1.1
 Metastasis subtype   1.0  
  MetA (n = 46)   1.6 0.52–5.2
  MetB (n = 12) 0.40 0.58 0.25–1.3
  MetC (n = 8) 0.20   
  1. Variables with a P-value below 0.05 (shown in bold) in univariate survival analysis were taken further into multivariate analysis
  2. #Metastasis subtypes according to [12]