Skip to main content
Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic mechanisms underlying prostate cancer radioresistance

Fig. 3

Radiation-induced epigenetic reprograming in PCa. Epigenetic mechanism regulation plays a key role in PCa radiation response, contributing to cell cycle deregulation, active DNA damage repair, and apoptosis evasion. A Aberrant gene expression is mediated by high DNMT activity at specific CpG sites. This mechanism allows DNA damage repair efficacy and apoptosis evasion. B Histone post-translational modifications are able to modulate cell growth, CSC and EMT gene signature, and cell cycle deregulation. Uncontrolled PCa cell proliferation is maintained by an imbalance between repressive and activating markers. Black filled circles represent methylated sites. ALDH1A1, aldehyde dehydrogenase 1 family member A1; AR, androgen receptor; AKT, protein kinase B; BRCA1, breast cancer type 1; CSC, cancer stem cells; DNMT, DNA methyltransferase; EMT, epithelial-mesenchymal transition; ERK, extracellular regulated kinase; EZH2, enhancer of zeste homolog 2; HDAC, histone deacetylase; MEK, mitogen-activated protein kinase; mTOR, mechanistic target of rapamycin kinase; PI3K, phosphoinositide 3-kinase

Back to article page