Fig. 2
From: Epigenetic mechanisms underlying prostate cancer radioresistance
Epigenetic landscape in PCa. Aberrant DNA methylation (A) and histone post-translational modifications (B, C) lead to overall PCa progression and aggressiveness due to uncontrolled gene transcription signature. Black filled circles represent methylated sites (A). ac, acetylation; APC, adenomatous polyposis coli; AR, androgen receptor; CBP, CREB-binding protein; CCND2, cyclin D2; CDNK2A, cyclin-dependent kinase inhibitor 2A; CpG, cytosine/guanine enriched sites; EZH2, enhancer of zeste homolog 2; GSTP1, glutathione S-transferase Pi 1; HDAC, histone deacetylase; HOXD3, homeobox protein Hox-D3; KDM, lysine demethylase; me, methylation; MGMT, O6-methylguanine-DNA methyltransferase; PCa, prostate cancer; PTGS2, prostaglandin-endoperoxide synthase 2; RARβ2, retinoic acid receptor beta 2; RASSF1A, Ras association domain family member 1; SIRT, sirtuin; TGS, tumor suppressor genes