Fig. 4

DMR analysis of predicting future LIM status using CRC primary tumors. A Flow chart for predictive DMRs using LASSO-based LOOCV. B Receiver operating characteristic curve of the 23 predictive DMR markers in 59 primary CRC tumor samples. C Receiver operating characteristic curve of the 23 predictive DMR markers in 11 metastasis CRC tumor samples (6 LIM, 5 LUM). D Liver metastasis-free survival for the 59 CRC patients with and without LIM. E Principal Component Analysis of the 23 predictive DMRs in 81 samples. F Heatmap of the 23 predictive DMR marker methylation values in 59 primary tumor samples with future LIM status