Skip to main content
Fig. 5 | Clinical Epigenetics

Fig. 5

From: Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance

Fig. 5

The main CSCs signaling pathways regulation by epigenetic mechanisms. Epigenetic deregulation of CSC-related signaling pathways enables cancer cells to obtain self-renewal properties and drug resistance characteristics. Hedgehog signaling pathway can be activated by Shh promoter hypomethylation and enhance HDAC1 expression. Wnt/β-catenin signaling can be strengthened by reduced DKK1 inhibitor expression of it via promoter hypermethylation and enhanced H3K27me3 and reduced acetylation at H3K16. Notch signaling focus on genes including Hes1 and Hes5 which can be active by STRAP at their promoter region

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us