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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance

Fig. 2

Schematic representation of the cancer stem cell microenvironment or niche. Progression of tumor needs a cooperative interplay between CSCs and their niche. The CSC niche made of various cells including mesenchymal stem cells (MSCs), endothelial cells, cancer-associated fibroblasts (CAFs) and immune cells, tumor-associated macrophages (TAMs), regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), T cells and B cells. These cells secrete various growth factors and cytokines which promote tumorigenesis, tumor progression, and immunosuppression

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Clinical Epigenetics

ISSN: 1868-7083

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