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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Chromatin accessibility changes at intergenic regions are associated with ovarian cancer drug resistance

Fig. 4

Relationship between chromatin changes at COREs and gene expression. a Distribution of t statistics of difference in expression for differentially expressed genes near COREs lost or gained in the resistant line in each pair. Differentially expressed genes show log2FC > ± 2 and FDR < 0.05. Red lines show distribution of t statistics for differentially expressed genes near COREs gained in resistant lines, blue lines show t statistics for differentially expressed genes near COREs lost in resistant lines. b Odds ratios of differentially expressed genes being found near COREs lost or gained in resistant lines compared to their sensitive counterpart. Bars show odds ratios and error bars confidence intervals from Fisher’s exact test. *p < 0.05; ***p < 0.001.

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Clinical Epigenetics

ISSN: 1868-7083

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