Table 2 Detailed information of the four CRC patients with POLE proofreading mutations
ID | Sex | Age | POLE mutational spectrum | Tumour location | Histology | UICC stage | Â | Â | Â | Â | Â | Recurrence | Methylation rate | CD8(/HPF) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | MLH1 | MGMT | SFRP2 | ||||||||||||
T | N | M | ly | v | AB | C | Mp | Eh | R1 | R2 | |||||||||
123 | F | 63 | S459F | Ascending colon | mod | IIA | 3 | 0 | 0 | 0 | 0 | No | 45.1 | 0.0 | 0.0 | 0.0 | 43.7 | 35.8 | 110 |
777 | F | 61 | P286R | Ascending colon | mod | IIA | 3 | 0 | 0 | 0 | 0 | No | 74.1 | 0.0 | 0.0 | 0.0 | 61.9 | 45.6 | 39 |
945 | M | 45 | P286R | Ascending colon | mod | IIA | 3 | 0 | 0 | 0 | 1 | No | 0.0 | 0.0 | 0.0 | 0.0 | 91.8 | 69.9 | 25 |
596 | M | 41 | V411L | Ascending colon | mod > muc | I | 1 | 0 | 0 | 0 | 0 | No | 0.0 | 0.0 | 0.0 | 0.0 | 58.7 | 18.2 | 3 |