Fig. 2From: Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutationsDetection of POLE proofreading mutations. Among 1,070 CRC tissues analysed, pathogenic somatic POLE proofreading mutations were detected in four CRCs (two cases were p.P286R [c.857C > G], one was p.V411L [c.1231G > C], and one was p.S459F [c.1376C > T]) and DNA from their corresponding normal mucosa displayed no germline mutationsBack to article page