Fig. 3

Epigenetics changes during the proliferative and secretory phases in endometrial cells. a. During the proliferative phase, the enrichment of H3K27me3 on the HOXA10, PRL, and IGFBP-1 promoters in endometrial stromal cells (ESC) is reported, which is consistent with the lack of expression of these genes. Also, an increase in the expression of EZH2, which catalyzes the H3K27me3 modification, is observed. b. A decrease in the enrichment of H3K27me3 in the HOXA10, PRL, and IGFBP-1 promoters in decidual stromal cells (DSC) during the secretory phase is reported; consequently, an increase in the expression of these genes is observed. Furthermore, a decrease in the expression of EZH2 during decidualization is observed in DSC. During the secretory phase, some miRNAs, lncRNAs, and the proteins involved in their biogenesis increase their expression compared to the proliferative phase, such as miRNA-222, miR-543, and DICER in DSC, and miR-29c, DROSHA, H19, and PTENP1 in endometrial epithelial cells (EEC)