Fig. 4
From: Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
Oral bioavailability and target prediction of HDAC inhibitors and DNMT inhibitors. We used the online tool SwissADME (https://www.sib.swiss/) to predict the oral bioavailability and target prediction of 5 epi-drugs that represent HDAC inhibitors or DNMT inhibitors. The colored zone is the suitable physiochemical space for oral bioavailability. The pink area represents the optimal range for each property. Lipophility: -0.7 < XLOGP3 <  + 5.0; size: 150 g/mol < MV < 500 g/mol; polarity: 20Å2 < TPSA < 130Å2; insolubility: 0 < log S (ESOL) < 6; insaturation: 0.25 < fraction Csp3 < 1; flexibility: 0 < num. rotatable bonds < 9. The pie chart of each inhibitor displays the summary of predication target classes