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Table 5 Correlation of NEFM transcriptional expression/DNA methylation with MHC molecules based on TISIDB database

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

MHC molecules

NEFM expression

NEFM DNA methylation

TISIDB rho, n = 1100

p

TISIDB rho, n = 785

p

B2M

− 0.11

0.00025

− 0.287

2.85e−16

HLA-A

− 0.093

0.00205

− 0.3

1.23e−17

HLA-B

− 0.089

0.00388

− 0.315

1.58e−19

HLA-C

− 0.077

0.0107

− 0.212

2.35e−09

HLA-DMA

0.058

0.0561

− 0.405

 < 2.2e−16

HLA-DMB

0.03

0.313

− 0.414

 < 2.2e−16

HLA-DOA

0.156

2.16e−07

− 0.458

 < 2.2e−16

HLA-DOB

0.034

0.266

− 0.503

 < 2.2e−16

HLA-DPA1

0.084

0.00511

− 0.407

 < 2.2e−16

HLA-DPB1

0.153

3.46e−07

− 0.435

 < 2.2e−16

HLA-DQA1

0.061

0.0446

− 0.398

 < 2.2e−16

HLA-DQA2

0.057

0.058

− 0.294

5.78e−14

HLA-DQB1

0.081

0.00747

− 0.352

 < 2.2e−16

HLA-DRA

0.061

0.0447

− 0.434

 < 2.2e−16

HLA-DRB1

0.089

0.00329

− 0.39

 < 2.2e−16

HLA-E

0.05

0.0991

− 0.484

 < 2.2e−16

HLA-F

 − 0.028

0.358

− 0.377

 < 2.2e−16

HLA-G

 − 0.04

0.189

− 0.231

6.32e−11

TAP1

 − 0.204

8.63e−12

− 0.267

3.39e−14

TAP2

 − 0.176

4.89e−09

− 0.381

 < 2.2e−16

TAPBP

− 0.143

1.91e−06

− 0.057

0.109

  1. Significant p value < 0.05 is in bold
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Clinical Epigenetics

ISSN: 1868-7083

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