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Table 4 Correlation of NEFM transcriptional expression/DNA methylation with immunomodulators based on TISIDB and TCGA database

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

Immunomodulators NEFM expression NEFM DNA methylation
TISIDB rho, n=1100
(TCGA R, n = 808)
p TISIDB rho, n=785
(TCGA R, n = 808)
P
ADORA2A 0.137 (0.15) 5.07e−6 (2.5e−05) − 0.095 (− 0.004) 0.00751 (0.26)
BTLA 0.032 (0.041) 0.296 (0.240) − 0.477 (− 0.35) 2.2e−16
CD160 − 0.019 (0.07) 0.539 (0.046) − 0.157 (− 0.15) 9.61e−06 (1.5e−05)
CD244 0.06 (0.076) 0.0467 (0.032) − 0.525 (− 0.35)  < 2.2e−16
CD274(PD-L1) − 0.006 (0.038) 0.854 (0.28) − 0.304 (− 0.28) 4.23e−18 (2.3e−15)
CD96 0.037 (0.042) 0.226 (0.23) − 0.479 (− 0.34)  < 2.2e−16
CSF1R 0.132 (0.11) 0.22e−05 (0.0027) − 0.44 (− 0.34)  < 2.2e−16
CTLA4 − 0.028 (0.00073) 0.357 (0.98) − 0.432 (0.3)  < 2.2e−16
HAVCR2 0.008 (− 0.0079) 0.789 (0.82) − 0.298 (− 0.21) 2.16e−17 (1.8e−09)
IDO1 − 0.112 (− 0.1) 0.000203 (0.0036) − 0.384 (− 0.26)  < 2.2e−16 (1.2e−13)
IL10 − 0.003 (− 0.025) 0.921 (0.48) − 0.388 (− 0.29)  < 2.2e−16
IL10RB − 0.08 (− 0.036) 0.00821 (0.31) − 0.262 (− 0.2) 1.08e−13 (1.3e−08)
KDR(VEGFR) 0.127 (0.11) 2.51e−05 (0.0017) − 0.117 (− 0.15) 0.000984 (2.9e−05)
LAG3 − 0.171 (− 0.14) 1.11e−08 (4.5e−05) − 0.314 (− 0.2) 2.38e−19 (6.9e−09)
LGALS9 − 0.051 (− 0.059) 0.0912 (0.093) − 0.293 (− 0.17) 9.15e−17 (1.2e−06)
PDCD1 0.007 (0.023) 0.816 (0.51) − 0.43 (− 0.29)  < 2.2e−16
PDCD1LG2 0.066 (0.076) 0.0281 (0.031) − 0.476 (− 0.34)  < 2.2e−16
PVRL2(NECTIN2) 0.027 (0.045) 0.378 (0.2) 0.32 (0.14) 2.9e−20 (9.9e−05)
TGFB1 0.32 (0.3)  < 2.2e−16 − 0.28 (− 0.2)3) 1.91e−15 (3.6e−11)
TGFBR1 0.214 (0.21) 9.26e−13 (2.7e−09) − 0.178 (− 0.13) 5.46e−07 (0.00014)
TGFBR2 (0.35)  < 2.2e−16 (− 0.33)  < 2.2e−16
TIGIT − 0.02 (− 0.0034) 0.509 (0.92) − 0.446 (− 0.31)  < 2.2e−16
VTCN1 0.207 (0.21) 4.34e−12 (2.4e−09) − 0.175 (− 0.07) 8.63e−07 (0.048)
C10orf54(VSIR, VISTA) 0.205 (0.18) 7.97e−12 (2.3e−07) − 0.552 (− 0.39)  < 2.2e−16
CD27(TNFRSF7) 0.097 ( (0.11) 0.00121 (0.0013) − 0.452 (− 0.31)  < 2.2e−16
CD276 0.168 (0.19) 2.12e−08 (9.7e−08) − 0.038 (− 0.065) 0.284 (0.068)
CD28 0.042 (0.038) 0.16 (0.28) − 0.458 (− 0.33)  < 2.2e−16
CD40 0.137 (0.15) 5.1e−06 (2.2e−05) − 0.553 (− 0.38)  < 2.2e−16
CD40LG 0.088 (0.093) 0.00346 (0.0081) − 0.457 (0.32)  < 2.2e−16
CD48 0.062 (0.062) 0.0391 (0.079) − 0.458 (− 0.31)  < 2.2e−16
CD70 0.108 (0.11) 0.000345 (0.0017) − 0.312 (− 0.17) 3.39e−19 (1.4e−06)
CD80 − 0.069 0.0228 − 0.259 (− 0.18) 1.95e−13 (2.8e−07)
CD86 − 0.028 (− 0.056) 0.357 (0.11) − 0.375  < 2.2e−16
CXCL12 0.467 (0.43)  < 2.2e−16 − 0.32 (− 0.2) 3.31e−20 (1.5e−08)
CXCR4 0.053 (0.087) 0.0763(0.013) − 0.313 (− 0.17) 3.11e−19 (8.2e−07)
ENTPD1(CD39) 0.267 (0.3) 2.85e−19 (< 2.2e−16) − 0.271 (− 0.23) 1.46e−14 (5.5e−11)
ICOS − 0.064 (− 0.044) 0.0341 (0.21) − 0.42 (− 0.29)  < 2.2e−16
ICOSLG 0.045 (0.0042) 0.15 (0.91) − 0.193 (− 0.027) 5.69e−08 (0.44)
IL2RA − 0.033 (− 0.022) 0.276 (0.53) − 0.454 (− 0.33)  < 2.2e−16
IL6 0.091 (0.087) 0.00266 (0.014) − 0.425 (− 0.3)  < 2.2e−16
IL6R − 0.012 (− 0.015) 0.7 (0.67) − 0.341 (− 0.29)  < 2.2e−16
KLRC1 0.004 (0.017) 0.907 (0.64) − 0.386 (− 0.28)  < 2.2e−16 (2.7e−16)
KLRK1 0.041 (0.075) 0.171 (0.033) − 0.456 (− 0.28)  < 2.2e−16 (4.3e−16)
LTA − 0.033 (− 0.015) 0.273 (0.66) − 0.413 (− 0.28)  < 2.2e−16 (1e−15)
MICB 0.003 (− 0.0094) 0.93 (0.79) − 0.047 (− 0.16) 0.186(3e−06)
NT5E(CD73) 0.224 (0.2) 6.85e−14 (1e−08) − 0.306 (− 0.28) 2.26e−18 (5.6e−16)
PVR − 0.204 (− 0.17) 1.05e−11 (8.9e−07) − 0.134 (− 0.11) 0.00017 (0.0019)
RAET1E 0.094 (0.12) 0.00182 (0.00065) − 0.073 (− 0.016) 0.0411 (0.65)
TMEM173(STING) 0.231 (0.2) 1.14e−14 (6.5e−09) − 0.263 (− 0.19) 9.54e−14 (1.1e−07)
TNFRSF13B 0.202 (0.21) 1.39e−11 (3.8e−09) − 0.419 (− 0.31)  < 2.2e−16
TNFRSF13C 0.068 (0.027) 0.0237 (0.44) − 0.346 (− 0.26)  < 2.2e−16 (4.6e−14)
TNFRSF14 0.048 (0.055) 0.109 (0.12) − 0.074 (0.044) 0.0377 (0.21)
TNFRSF17 0.113 (0.13) 0.000181(0.00037) − 0.396 (− 0.27)  < 2.2e−16 (3.9e−15)
TNFRSF18 − 0.029 (− 0.04) 0.335 (0.25) 0.064 (− 0.021) 0.0727 (0.00037)
TNFRSF25 0.014 (0.078) 0.646 (0.028) − 0.257 (− 0.14) 3.01e−13 (4.3e−05)
TNFRSF4 0.082 (0.082) 0.00664 (0.019) − 0.281 (− 0.18) 1.51e−15 (2.9e−07)
TNFRSF8 0.086 (0.085) 0.00424 (0.015) − 0.529 (− 0.37)  < 2.2e−16
TNFRSF9 0.03 (0.036) 0.319 (0.3) − 0.443 (− 0.36)  < 2.2e−16
TNFSF13 − 0.015 (0.028) 0.617 (0.42) 0.047 (0.075) 0.189 (0.035)
TNFSF13B − 0.015 (− 0.025) 0.623 (0.48) − 0.343 (− 0.25)  < 2.2e−16 (1.3e−12)
TNFSF14 0.082 (0.084) 0.00622 (0.017) − 0.45 (− 0.32)  < 2.2e−16
TNFSF15 0.095 (0.085) 0.00153 (0.015) − 0.201 (− 0.12) 1.36e−08 (0.00091)
TNFSF4 0.149 (0.17) 6.77e−07 (2.1e−06) − 0.081 (− 0.096) 0.0228 (0.0064)
TNFSF9 0.024 (0.086) 0.00165 (0.015) − 0.256 (− 0.11) 3.82e−13 (0.0012)
ULBP1 (NKG2D) − 0.029 (0.0054) 0.333 (0.88) − 0.159 (− 0.015) 7.37e−06 (0.68)
  1. Significant p value < 0.05 is in bold