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Table 2 Univariable and multivariable Cox proportional hazards regression models of NEFM expression with clinicopathological features in TCGA BRCA cohort

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

Characteristics Univariate Multivariate
HR CI95 p HR CI95 p
Subgroup 1.03 0.89–1.2 0.648    
Stage 1.8 1.38–2.35  < 0.001 1.83 1.34–2.51  < 0.001
NEFM 0.53 0.36–0.8 0.002 0.58 0.36–0.95 0.031
Age 1.03 1.02–1.05  < 0.001 1.03 1.01–1.05 0.001
ER 0.56 0.37–0.85 0.007 0.62 0.3–1.28 0.198
PR 0.6 0.4–0.9 0.013 0.67 0.33–1.37 0.271
HER2 1.75 1.09–2.8 0.021 1.61 0.96–2.69 0.071
  1. HR: hazard ratio; CI 95: 95% confidence interval; subgroup: luminal A, luminal B, positive HER2, basal, normal; stage: I, II, III, IV; NEFM: low or high expression by median. Age, ER, PR, HER2 was divided into two groups according to the median, respectively. Significant p values < 0.05 are in bold