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Table 2 Univariable and multivariable Cox proportional hazards regression models of NEFM expression with clinicopathological features in TCGA BRCA cohort

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

Characteristics

Univariate

Multivariate

HR

CI95

p

HR

CI95

p

Subgroup

1.03

0.89–1.2

0.648

   

Stage

1.8

1.38–2.35

 < 0.001

1.83

1.34–2.51

 < 0.001

NEFM

0.53

0.36–0.8

0.002

0.58

0.36–0.95

0.031

Age

1.03

1.02–1.05

 < 0.001

1.03

1.01–1.05

0.001

ER

0.56

0.37–0.85

0.007

0.62

0.3–1.28

0.198

PR

0.6

0.4–0.9

0.013

0.67

0.33–1.37

0.271

HER2

1.75

1.09–2.8

0.021

1.61

0.96–2.69

0.071

  1. HR: hazard ratio; CI 95: 95% confidence interval; subgroup: luminal A, luminal B, positive HER2, basal, normal; stage: I, II, III, IV; NEFM: low or high expression by median. Age, ER, PR, HER2 was divided into two groups according to the median, respectively. Significant p values < 0.05 are in bold
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Clinical Epigenetics

ISSN: 1868-7083

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