From: DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas
Variables | Lower-grade gliomas (%) | |
---|---|---|
Grade II, n = 74 | Grade III, n = 92 | |
Gender | ||
Female | 26 (35) | 40 (43) |
Ratio male:female | 1.9 | 1.3 |
Age at diagnosis—years | ||
Mean ± SD | 48 ± 13.5 | 41 ± 13.6 |
Age at diagnosis—groups | ||
18–29 | 7 (9) | 16 (17) |
30–39 | 17 (23) | 24 (26) |
40–49 | 17 (23) | 23 (25) |
50–59 | 16 (22) | 21 (23) |
60–69 | 15 (20) | 6 (7) |
≥ 70 | 2 (3) | 2 (2) |
Tumor location | ||
Frontal | 40 (54) | 51 (55) |
Insular | 3 (4) | 3 (3) |
Occipital | 1 (1) | 2 (2) |
Parietal | 6 (8) | 11 (12) |
Temporal | 24 (32) | 24 (26) |
Basal ganglia | 0 | 1 (1) |
Type of surgery | ||
Biopsy | 6 (8) | 2 (2) |
Resection | 68 (92) | 90 (98) |
Size of tumor | ||
< 4 cm | 17 (23) | 14 (15) |
4–6 cm | 31 (42) | 49 (53) |
> 6 cm | 26 (35) | 29 (32) |
Histopathological diagnosis (WHO 2007) | ||
Astrocytoma | 45 (61) | 46 (50) |
Oligoastrocytoma | 15 (20) | 30 (33) |
Oligodendroglioma | 14 (19) | 16 (17) |
Molecular biomarkers | ||
IDH-mutant | 14 (19) | 1 (1) |
IDH-wildtype | 2 (3) | 4 (4) |
1p/19q codeletion | 18 (24) | 14 (15) |