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Table 1 Clinical characteristics of the studied population with diffuse lower-grade gliomas (n = 166)

From: DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

Variables

Lower-grade gliomas (%)

Grade II, n = 74

Grade III, n = 92

Gender

 Female

26 (35)

40 (43)

 Ratio male:female

1.9

1.3

Age at diagnosis—years

 Mean ± SD

48 ± 13.5

41 ± 13.6

Age at diagnosis—groups

 18–29

7 (9)

16 (17)

 30–39

17 (23)

24 (26)

 40–49

17 (23)

23 (25)

 50–59

16 (22)

21 (23)

 60–69

15 (20)

6 (7)

 ≥ 70

2 (3)

2 (2)

Tumor location

 Frontal

40 (54)

51 (55)

 Insular

3 (4)

3 (3)

 Occipital

1 (1)

2 (2)

 Parietal

6 (8)

11 (12)

 Temporal

24 (32)

24 (26)

 Basal ganglia

0

1 (1)

Type of surgery

 Biopsy

6 (8)

2 (2)

 Resection

68 (92)

90 (98)

Size of tumor

 < 4 cm

17 (23)

14 (15)

 4–6 cm

31 (42)

49 (53)

 > 6 cm

26 (35)

29 (32)

Histopathological diagnosis (WHO 2007)

 Astrocytoma

45 (61)

46 (50)

 Oligoastrocytoma

15 (20)

30 (33)

 Oligodendroglioma

14 (19)

16 (17)

Molecular biomarkers

 IDH-mutant

14 (19)

1 (1)

 IDH-wildtype

2 (3)

4 (4)

 1p/19q codeletion

18 (24)

14 (15)

  1. SD, Standard deviation